background: we aimed at evaluating the toxicity effects of low (subtoxic) concentrations of silver nanoparticles (agnp, 5-10 nm) in human hepatoblastoma (hepg2) cell line after and during a period of about one month. methods: xtt and mtt assays were used to draw a dose-response curve ic50 (half maximal inhibitory concentration) value of the agnp on hepg2 cells was calculated to be 2.75-3.0 mg/l...

fractions obtained from partitioning of aerial methanolic extract of euphorbia aellenii with chloroform (e2), ethyl acetate (e3), n-butanol (e4) and water (e5) were investigated in vitro for their phytotoxicity, insecticidal, anti-leishmanial, cytotoxicity, antibacterial and antifungal activities. sample e2 appeared to have significant phytotoxic activity. in the insecticidal screening study on...

pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. in this study, b3 p 86 / 6 – 31 + + g * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. several statisti...

background cancer is one of the leading causes of human death. the discovery of new generations of low-cost anticancer drugs with high efficacy and low toxicity is necessary, and is only possible by screening medicinal plants with prior knowledge. objectives in this study, the bioactivities of three medicinal plants from india, including alstonia scholaris, alstonia venenata, and moringa oleife...

the essential oil from the aerial parts ofjurinea leptoloba dc., collected from shiraz (south of iran), was investigated for total phenolic content (tpc), antioxidant and cytotoxic effects. tpc of j. leptoloba oil was determined to be 16.53 ± 5.69 μg gallic acid equivalent/mg sample (μg gae/mg oil) using the folin-ciocalteau assay. the ferric reducing power of the oil was determined 0.117 ± 0.0...

introduction: the aims of this study were i) to define the chemical constituents of cuminum cyminum (cumin) essential oil, ii) to compare the antimicrobial activity of this oil to that of chlorhexidine (chx) and co-trimoxazole on planktonic and biofilm forms of bacteria isolated from the teeth with persistent endodontic infection and iii ) to compare the cytotoxicity of these medicaments on l92...

objective(s): for the development of reliable, ecofriendly, less expensive process for the synthesis of silver nanoparticles and to evaluate the bactericidal, and cytotoxicity properties of silver nanoparticles synthesized from root extract of croton bonplandianum, baill. materials and methods: the synthesis of silver nanoparticles by plant part of croton bonplandianum was carried out.  the for...

safety and beneficence of farm animal nutrition plays a great role in their healthy life which in turn have impact on human nutrition via diary or meat products. assessing safety and beneficence of vicia varibilis freyn and sint. which is chosen intrinsically by domesticated animals of kohgiluyehand boyerahmad iranis the aim of the present work. our results not only show no cytotoxic activity i...

some dorema species are used in persian traditional medicine. in the present study the total extract from the roots of dorema hyrcanum koso-pol. was investigated for its in vitro (pldh assay) and in vivo (peters’ 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line mdbk (mtt test). the ic50 values for a chloroquine- sensitive (3d7) and a chl...

background: the use of natural products as anticancer and antioxidant agents has a long history. several drugs currently used in chemotherapy were isolated from plant species. objective: the aim of this study was to evaluate cytotoxicity and antioxidant activity as well as phenol and flavonoid contents of five plant species of solanaceae family. methods: five plant species of solanaceae family ...